Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies

DR Skvarc, M Berk, LK Byrne, OM Dean, S Dodd… - Neuroscience & …, 2018 - Elsevier
Abstract Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with
significant clinical, social and financial impacts for patients and their communities. The …

Bioinorganic chemistry of Alzheimer's disease

KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

N‐acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities

R Bavarsad Shahripour, MR Harrigan… - Brain and …, 2014 - Wiley Online Library
Background There is an expanding field of research investigating the benefits of medicines
with multiple mechanisms of action across neurological disorders. N‐acetylcysteine (NAC) …

[HTML][HTML] Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease

DA Butterfield, MP Mattson - Neurobiology of disease, 2020 - Elsevier
Inheritance of apolipoprotein E4 (APOE4) is a major risk factor for development of
Alzheimer's disease (AD). This lipoprotein, in contrast to apoE2, has arginine residues at …

[HTML][HTML] Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia

R Obeid, W Herrmann - FEBS letters, 2006 - Elsevier
Mild to moderate hyperhomocysteinemia is a risk factor for neurodegenerative diseases.
Human studies suggest that homocysteine (Hcy) plays a role in brain damage, cognitive and …

Resveratrol—a boon for treating Alzheimer's disease?

TS Anekonda - Brain research reviews, 2006 - Elsevier
Resveratrol, a red wine polyphenol, is known to protect against cardiovascular diseases and
cancers, as well as to promote antiaging effects in numerous organisms. It also modulates …

Oxidative stress and metabolic syndrome: cause or consequence of Alzheimer′ s disease?

D Luque-Contreras, K Carvajal… - Oxidative medicine …, 2014 - Wiley Online Library
Alzheimer's disease (AD) is a major neurodegenerative disease affecting the elderly.
Clinically, it is characterized by a progressive loss of memory and cognitive function …

Neuronal apoptosis in neurodegeneration

M Okouchi, O Ekshyyan, M Maracine… - Antioxidants & redox …, 2007 - liebertpub.com
Apoptosis mediates the precise and programmed natural death of neurons and is a
physiologically important process in neurogenesis during maturation of the central nervous …

N-acetylcysteine and neurodegenerative diseases: basic and clinical pharmacology

M Arakawa, Y Ito - The Cerebellum, 2007 - Springer
Increasing lines of evidence suggest a key role of oxidative stress in neurodegenerative
diseases. Alzheimer's disease, Parkinson's disease, myoclonus epilepsy of the Unverricht …

B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE …

A Fuso, V Nicolia, RA Cavallaro, L Ricceri… - Molecular and cellular …, 2008 - Elsevier
Etiological and molecular studies on the sporadic form of Alzheimer's disease have yet to
determine the underlying mechanisms of neurodegeneration. Hyperhomocysteinemia is …