[HTML][HTML] The mechanisms of pharmacokinetic food-drug interactions–A perspective from the UNGAP group
The simultaneous intake of food and drugs can have a strong impact on drug release,
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …
Nanodiscs: a versatile nanocarrier platform for cancer diagnosis and treatment
J Bariwal, H Ma, GA Altenberg, H Liang - Chemical Society Reviews, 2022 - pubs.rsc.org
Cancer therapy is a significant challenge due to insufficient drug delivery to the cancer cells
and non-selective killing of healthy cells by most chemotherapy agents. Nano-formulations …
and non-selective killing of healthy cells by most chemotherapy agents. Nano-formulations …
Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
Lanthanide complexes as chiral probes exploiting circularly polarized luminescence
Optical probes that provide information about local chirality have been developed based on
changes to the circular polarisation of emitted light. Highly emissive complexes of lanthanide …
changes to the circular polarisation of emitted light. Highly emissive complexes of lanthanide …
The journey of a drug-carrier in the body: an anatomo-physiological perspective
N Bertrand, JC Leroux - Journal of controlled release, 2012 - Elsevier
Recent advances in chemistry and material sciences have witnessed the emergence of an
increasing number of novel and complex nanosized carriers for the delivery of drugs and …
increasing number of novel and complex nanosized carriers for the delivery of drugs and …
Stable polymer nanoparticles with exceptionally high drug loading by sequential nanoprecipitation
Poor solubility often leads to low drug efficacy. Encapsulation of water‐insoluble drugs in
polymeric nanoparticles offers a solution. However, low drug loading remains a critical …
polymeric nanoparticles offers a solution. However, low drug loading remains a critical …
Amphiphile nanoarchitectonics: from basic physical chemistry to advanced applications
M Ramanathan, LK Shrestha, T Mori, Q Ji… - Physical Chemistry …, 2013 - pubs.rsc.org
Amphiphiles, either synthetic or natural, are structurally simple molecules with the
unprecedented capacity to self-assemble into complex, hierarchical geometries in …
unprecedented capacity to self-assemble into complex, hierarchical geometries in …
A review of food–drug interactions on oral drug absorption
Food effect, also known as food–drug interactions, is a common phenomenon associated
with orally administered medications and can be defined as changes in absorption rate or …
with orally administered medications and can be defined as changes in absorption rate or …
Bioinspired core–shell nanoparticles for hydrophobic drug delivery
A large range of nanoparticles have been developed to encapsulate hydrophobic drugs.
However, drug loading is usually less than 10% or even 1%. Now, core–shell nanoparticles …
However, drug loading is usually less than 10% or even 1%. Now, core–shell nanoparticles …
Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery
Lipid nanoparticles (LNPs) are formulated using unmodified cholesterol. However,
cholesterol is naturally esterified and oxidized in vivo, and these cholesterol variants are …
cholesterol is naturally esterified and oxidized in vivo, and these cholesterol variants are …