There is an increasing amount of evidence that biomolecular condensates are linked to
neurodegenerative diseases associated with protein aggregation, such as Alzheimer's …

Aberrant aggregation of the misfolded presynaptic protein, α-Synuclein (α-Syn) into Lewy
body (LB) and Lewy neuritis (LN) is a major pathological hallmark of Parkinson's disease …

Liquid-liquid phase separation (LLPS) has emerged as a crucial biological phenomenon
underlying the sequestration of macromolecules (such as proteins and nucleic acids) into …

The maturation of liquid-like protein condensates into amyloid fibrils has been associated
with several neurodegenerative diseases. However, the molecular mechanisms underlying …

Protein liquid–liquid phase separation can lead to disease-related amyloid fibril formation.
The mechanisms of conversion of monomeric protein into condensate droplets and of the …

At the turn of the twenty-first century, fundamental changes took place in the understanding
of the structure and function of proteins and then in the appreciation of the intracellular …

Amyloid fibrils are supramolecular homopolymers of proteins that play important roles in
biological functions and disease. These objects have received an exponential increase in …

The aggregation of α-synuclein into amyloid fibrils has been under scrutiny in recent years
because of its association with Parkinson's disease. This process can be triggered by a lipid …

Membrane-less organelles assemble through liquid–liquid phase separation (LLPS) of
partially disordered proteins into highly specialized microenvironments. Currently, it is …

As a promising strategy, amorphous solid dispersion has been extensively employed in
improving the oral bioavailability of insoluble drugs. Despite the numerous advantages, the …