Gut microbial metabolites in lung cancer development and immunotherapy: Novel insights into gut-lung axis

X Li, S Shang, M Wu, Q Song, D Chen - Cancer Letters, 2024 - Elsevier
Metabolic derivatives of numerous microorganisms inhabiting the human gut can participate
in physiological activities and immune status of the lungs through the gut-lung axis. The …

Obesity, dysbiosis and inflammation: Interactions that modulate the efficacy of immunotherapy

AS Yende, D Sharma - Frontiers in immunology, 2024 - frontiersin.org
Recent years have seen an outstanding growth in the understanding of connections
between diet-induced obesity, dysbiosis and alterations in the tumor microenvironment. Now …

Liquid biopsy in lung cancer: biomarkers for the management of recurrence and metastasis

VGP Souza, A Forder, LJ Brockley… - International Journal of …, 2023 - mdpi.com
Liquid biopsies have emerged as a promising tool for the detection of metastases as well as
local and regional recurrence in lung cancer. Liquid biopsy tests involve analyzing a …

The role of intestinal flora on tumorigenesis, progression, and the efficacy of PD-1/PD-L1 antibodies in colorectal cancer

S Wang, B Xu, Y Zhang, G Chen… - Cancer Biology & …, 2023 - pmc.ncbi.nlm.nih.gov
Intestinal flora affects the maturation of the host immune system, serves as a biomarker and
efficacy predictor in the immunotherapy of several cancers, and has an important role in the …

Modulating gut microbiome in cancer immunotherapy: Harnessing microbes to enhance treatment efficacy

X Kang, HCH Lau, J Yu - Cell Reports Medicine, 2024 - cell.com
Immunotherapy has emerged as a robust approach against cancer, yet its efficacy has
varied among individuals, accompanied by the occurrence of immune-related adverse …

The association between aspirin use and immune-related adverse events in specific cancer patients receiving ICIs therapy: analysis of the FAERS database

H Yang, Z Liu, R Li, R Huang, X Peng - Frontiers in Pharmacology, 2023 - frontiersin.org
Background: The promise of immune checkpoint inhibitors (ICIs) therapy in cancer treatment
is tempered by the occurrence of immune-related adverse events (irAEs). Many patients …

Modulation of gut microbiota: a novel approach to enhancing the effects of immune checkpoint inhibitors

J Huang, C Gong, A Zhou - Therapeutic Advances in …, 2023 - journals.sagepub.com
Although immune checkpoint inhibitors (ICIs) have greatly improved the prognosis of some
cancer patients, the majority still fail to respond adequately, and the available biomarkers …

Mechanisms by which the intestinal microbiota affects gastrointestinal tumours and therapeutic effects

J He, H Li, J Jia, Y Liu, N Zhang, R Wang, W Qu… - Molecular …, 2023 - Springer
The intestinal microbiota is considered to be a forgotten organ in human health and disease.
It maintains intestinal homeostasis through various complex mechanisms. A significant body …

Immune‐related adverse events in non‐small cell lung cancer: Occurrence, mechanisms and therapeutic strategies

X Lin, M Xie, J Yao, X Ma, L Qin… - Clinical and …, 2024 - Wiley Online Library
The emergence of immune checkpoint inhibitors (ICIs) has heralded a transformative era in
the therapeutic landscape of non‐small cell lung cancer (NSCLC). While ICIs have …

[HTML][HTML] Decoding the microbiota metabolome in hepatobiliary and pancreatic cancers: Pathways to precision diagnostics and targeted therapeutics

Y Xu, J Le, J Qin, Y Zhang, J Yang, Z Chen, C Li… - Pharmacological …, 2024 - Elsevier
We delve into the critical role of the gut microbiota and its metabolites in the pathogenesis
and progression of hepatobiliary and pancreatic (HBP) cancers, illuminating an urgent need …