Background Safety and toxicity have become major challenges in the internationalization of
Chinese medicine. Inspite of its wide application, security problems of Chinese medicine still …

Ethnopharmacological relevance Bio-assay guided phytoextracts and derived
phytoconstituents reported having multipotent biological activities and nearly 60–80% of the …

Immune-mediated inflammation contributes to the development of psoriasis. However, long-
term treatment with global immunosuppressive agents may cause a variety of side effects …

Ethnopharmacological relevance Tripterygium wilfordii polyglycosides (TWP) are extracted
from Tripterygium wilfordii Hook. f., which has the significant effects of anti-inflammation and …

Abstract Background Tripterygium wilfordii Hook. f.(TwHf) belonging to the Celastraceae
family is widely used for psoriasis treatment, especially in topical therapy in Chinese …

Background Psoriasis is an autoimmune disease mediated by T cells. However, treatment
remains a clinical challenge because of its frequent recurrence. Celastrol (Cel), the main …

As the current treatment of chronic kidney disease (CKD) is limited, it is necessary to seek
more effective and safer treatment methods, such as Chinese herbal medicines (CHMs). In …

Abstract Introduction: Demethylzeylasteral (T-96), a new extract of Tripterygium wilfordii
Hook F, exerted immunomodulatory properties in autoimmune diseases, but its effect on …

Botanicals are widely consumed as dietary supplements, medicines, and consumer
products. Their chemical complexity and variability present challenges in safety assessment …

Ethnopharmacological relevance Tripterygium wilfordii polyglycosides (TWP), extracted from
the traditional Chinese herb Tripterygium wilfordii, has been widely used in the treatment of …