The mesolimbic hypothesis has been a central dogma of schizophrenia for decades,
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …

Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …

Schizophrenia is a complex neuropsychiatric syndrome with a heterogeneous genetic,
neurobiological, and phenotypic profile. Currently, no objective biological measures—that is …

Abstract Treatment-resistant schizophrenia (TRS), the persistence of positive symptoms
despite≥ 2 trials of adequate dose and duration of antipsychotic medication with …

The long‐term benefit‐to‐risk ratio of sustained antipsychotic treatment for schizophrenia
has recently been questioned. In this paper, we critically examine the literature on the long …

Background A lack of a sufficiently large sample at single sites causes poor generalizability
in automatic diagnosis classification of heterogeneous psychiatric disorders such as …

Abstract Since Emil Kraepelin's conceptualization of endogenous psychoses as dementia
praecox and manic depression, the separation between primary psychotic disorders and …

Background Current fMRI-based classification approaches mostly use functional
connectivity or spatial maps as input, instead of exploring the dynamic time courses directly …

Despite 50+ years of drug discovery, current antipsychotics have limited efficacy against
negative and cognitive symptoms of schizophrenia, and are ineffective—with the exception …

Schizophrenia is a chronic psychiatric disorder with a heterogeneous genetic and
neurobiological background that influences early brain development, and is expressed as a …