Genetic information is loaded on chromatin, which involves DNA sequence arrangement
and the epigenetic landscape. The epigenetic information including DNA methylation …

A network, whose nodes are genes and whose directed edges represent positive or
negative influences of a regulatory gene and its targets, is often used as a representation of …

We interrogated at nucleotide resolution the spatiotemporal order of chromatin changes that
occur immediately following a site-specific double-strand break (DSB) upstream of the PHO5 …

Origins of DNA replication are specified by the ordered recruitment of replication factors in a
cell-cycle–dependent manner. The assembly of the pre-replicative complex in G1 and the …

Epigenetic mechanisms contribute to gene regulation by altering chromatin accessibility
through changes in transcription factor (TF) and nucleosome occupancy throughout the …

Prior to initiation of DNA replication, the eukaryotic helicase, Mcm2-7, must be activated to
unwind DNA at replication start sites in early S phase. To study helicase activation within …

Chromatin is a tightly packaged structure of DNA and protein within the nucleus of a cell.
The arrangement of different protein complexes along the DNA modulates and is modulated …

Although nucleosome positioning is key to epigenetic regulation, how the DNA sequence
contributes to positioning remains elusive, especially in the context of transcription direction …

Finding causal relationships among biological entities is a core goal of systems biology. In
molecular biology, causal relationships are often encoded as simple graphs called gene …

Origins of DNA replication are specified by the ordered recruitment of replication factors in a
cell-cycle–dependent manner. The assembly of the pre-replicative complex in G1 and the …