The immunology of Epstein-Barr virus–induced disease
Epstein-Barr virus (EBV) is usually acquired silently early in life and carried thereafter as an
asymptomatic infection of the B lymphoid system. However, many circumstances disturb the …
asymptomatic infection of the B lymphoid system. However, many circumstances disturb the …
How I treat hemophagocytic lymphohistiocytosis
MB Jordan, CE Allen, S Weitzman… - Blood, The Journal …, 2011 - ashpublications.org
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation,
occurring as either a familial disorder or a sporadic condition, in association with a variety of …
occurring as either a familial disorder or a sporadic condition, in association with a variety of …
Second messenger role for Mg2+ revealed by human T-cell immunodeficiency
FY Li, B Chaigne-Delalande, C Kanellopoulou… - Nature, 2011 - nature.com
Abstract The magnesium ion, Mg2+, is essential for all life as a cofactor for ATP,
polyphosphates such as DNA and RNA, and metabolic enzymes, but whether it plays a part …
polyphosphates such as DNA and RNA, and metabolic enzymes, but whether it plays a part …
Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D
B Chaigne-Delalande, FY Li, GM O'Connor, MJ Lukacs… - Science, 2013 - science.org
The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free
magnesium (Mg2+) concentrations. Individuals with genetic deficiencies in MAGT1 have …
magnesium (Mg2+) concentrations. Individuals with genetic deficiencies in MAGT1 have …
Human immunity against EBV—lessons from the clinic
The mammalian immune system has evolved over many millennia to be best equipped to
protect the host from pathogen infection. In many cases, host and pathogen have coevolved …
protect the host from pathogen infection. In many cases, host and pathogen have coevolved …
Primary immunodeficiencies associated with EBV disease
JI Cohen - Epstein Barr Virus Volume 1: One Herpes Virus: Many …, 2015 - Springer
Epstein-Barr virus (EBV) infects nearly all humans and usually is asymptomatic, or in the
case of adolescents and young adults, it can result in infectious mononucleosis. EBV …
case of adolescents and young adults, it can result in infectious mononucleosis. EBV …
Evolution of our understanding of XIAP deficiency
ACA Mudde, C Booth, RA Marsh - Frontiers in Pediatrics, 2021 - frontiersin.org
X-linked inhibitor of apoptosis (XIAP) deficiency is a rare inborn error of immunity first
described in 2006. XIAP deficiency is characterised by immune dysregulation and a broad …
described in 2006. XIAP deficiency is characterised by immune dysregulation and a broad …
X-linked inhibitor of apoptosis (XIAP) deficiency: the spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis
C Speckmann, K Lehmberg, MH Albert… - Clinical …, 2013 - Elsevier
X-linked inhibitor of apoptosis (XIAP) deficiency caused by mutations in BIRC4 was initially
described in patients with X-linked lymphoproliferative syndrome (XLP) who had no …
described in patients with X-linked lymphoproliferative syndrome (XLP) who had no …
XIAP variants in male Crohn's disease
Y Zeissig, BS Petersen, S Milutinovic, E Bosse, G Mayr… - Gut, 2015 - gut.bmj.com
Objective The genetic basis of inflammatory bowel disease (IBD) is incompletely
understood. The aim of this study was to identify rare genetic variants involved in the …
understood. The aim of this study was to identify rare genetic variants involved in the …
Distinct mutations in STXBP2 are associated with variable clinical presentations in patients with familial hemophagocytic lymphohistiocytosis type 5 (FHL5)
J Pagel, K Beutel, K Lehmberg, F Koch… - Blood, The Journal …, 2012 - ashpublications.org
Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically determined
hyperinflammatory syndrome caused by uncontrolled immune response mediated by T …
hyperinflammatory syndrome caused by uncontrolled immune response mediated by T …