Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle
and transcription, as well as communication, metabolism, and apoptosis. The kinases are …

Endogenous pancreatic β cell regeneration is a potential strategy for β cell expansion or
neogenesis to treat diabetes. Regeneration can occur through stimulation of existing β cell …

Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
and amyotrophic lateral sclerosis (ALS), are caused by neuronal loss and dysfunction …

Cyclin-dependent kinase 5 (CDK5) protein plays an important role not only in the central
nervous system but also in the periphery, including immune response, regulation of insulin …

The unprecedented rise in life expectancy observed in the last decades is leading to a
global increase in the ageing population, and age-associated diseases became an …

Regenerating pancreatic β-cells is a potential curative approach for diabetes. We previously
identified the small molecule CID661578 as a potent inducer of β-cell regeneration, but its …

Diabetes can be caused by an insufficiency in β-cell mass. Here, we performed a genetic
screen in a zebrafish model of β-cell loss to identify pathways promoting β-cell regeneration …

Progression of β-cell loss in diabetes mellitus is significantly influenced by persistent
hyperglycemia. At the cellular level, a number of signaling cascades affect the expression of …

Aims/hypothesis Recovering functional beta cell mass is a promising approach for future
diabetes therapies. The aim of the present study is to investigate the effects of adjudin, a …

New nanoparticles and biomaterials are increasingly being used in biomedical research for
drug delivery, diagnostic applications, or vaccines, and they are also present in numerous …