Protein-catalyzed capture agents (PCCs) are synthetic and modular peptide-based affinity
agents that are developed through the use of single-generation in situ click chemistry …

High-throughput screening is an important component of the drug discovery process. The
screening of libraries containing hundreds of thousands of compounds requires assays …

The incidence of abdominal aortic aneurysms (AAAs) has substantially increased during the
last 20 years and their rupture remains the third most common cause of sudden death in the …

Here, we report a method for the one-pot ribosomal synthesis of macrocyclic depsipeptides.
This method is based on a Ser-Pro-Cys-Gly (SPCG) motif discovered by in vitro selection of …

Photo‐affinity adsorbents (ie, translucent matrices functionalized with ligands featuring light‐
controlled biorecognition) represent a futuristic technology for purifying labile biologics. In …

Solid phase screenings of one bead one compound (OBOC) libraries have been widely
used to find ligands with pharmacological and analytical uses, and to purify or detect …

Cyclic peptides, owing to their good stability, high resistance to exo-and to some extent endo-
peptidases, enhanced binding affinity and selectivity towards target biomolecules, are …

Cyclic peptides are of great interest as therapeutic compounds due to their potential for
specificity and intracellular activity, but specific compounds can be difficult to identify from …

A novel dual ring-opening/cleavage strategy to determine the sequence of cyclic peptides
from one bead, one compound libraries is described. The approach uses a photolabile …

One-bead-one-compound peptide libraries, developed following the top-down experimental
approach, have attracted great interest in the identification of potential ligands or active …