DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …

Single-stranded genomic DNA can fold into G-quadruplex (G4) structures or form DNA: RNA
hybrids (R loops). Recent evidence suggests that such non-canonical DNA structures affect …

ATRX is a tumor suppressor that has been associated with protection from DNA replication
stress, purportedly through resolution of difficult-to-replicate G-quadruplex (G4) DNA …

Background The histone variant H3. 3 is enriched at active regulatory elements such as
promoters and enhancers in mammalian genomes. These regions are highly accessible …

Endogenous retroviruses (ERVs) comprise a significant portion of mammalian genomes.
Although specific ERV loci feature regulatory roles for host gene expression, most ERV …

R-loops are atypical, three-stranded nucleic acid structures that contain a stretch of RNA:
DNA hybrids and an unpaired, single stranded DNA loop. R-loops are physiological relevant …

Cellular totipotency is critical for whole-organism generation, yet how totipotency is
established remains poorly illustrated. Abundant transposable elements (TEs) are activated …

Hematopoietic stem and progenitor cells (HSPCs) are a heterogeneous group of cells with
expansion, differentiation, and repopulation capacities. How HSPCs orchestrate the …

Simple Summary ATRX is one of the most frequently mutated tumor suppressor genes in
human cancers. ATRX protein is a chromatin remodeler and transcriptional regulator that is …