Regulation of innate immune signaling by IRAK proteins
M Pereira, RT Gazzinelli - Frontiers in Immunology, 2023 - frontiersin.org
The Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1R) families are of paramount
importance in coordinating the early immune response to pathogens. Signaling via most …
importance in coordinating the early immune response to pathogens. Signaling via most …
[HTML][HTML] Antibodies and tuberculosis
AJ Jacobs, J Mongkolsapaya, GR Screaton… - Tuberculosis, 2016 - Elsevier
Tuberculosis (TB) remains a major public health problem internationally, causing 9.6 million
new cases and 1.5 million deaths worldwide in 2014. The Bacillus Calmette-Guérin vaccine …
new cases and 1.5 million deaths worldwide in 2014. The Bacillus Calmette-Guérin vaccine …
Macrophage immunoregulatory pathways in tuberculosis
Macrophages, the major host cells harboring Mycobacterium tuberculosis (M. tb), are a
heterogeneous cell type depending on their tissue of origin and host they are derived from …
heterogeneous cell type depending on their tissue of origin and host they are derived from …
TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation
Mycobacterial cell-wall glycolipids elicit an anti-mycobacterial immune response via FcRγ-
associated C-type lectin receptors, including Mincle, and caspase-recruitment domain family …
associated C-type lectin receptors, including Mincle, and caspase-recruitment domain family …
Immunometabolism in tuberculosis
Immunometabolism, the study of the relationship between bioenergetic pathways and
specific functions of immune cells, has recently gained increasing appreciation. In response …
specific functions of immune cells, has recently gained increasing appreciation. In response …
New tuberculosis vaccine strategies: taking aim at un-natural immunity
Despite some major progress made in developing tuberculosis (TB) vaccine strategies, with
a dozen novel vaccines currently in the clinical pipeline, the world is still missing an effective …
a dozen novel vaccines currently in the clinical pipeline, the world is still missing an effective …
[HTML][HTML] Interleukin-10 family and tuberculosis: an old story renewed
Abstract The interleukin-10 (IL-10) family of cytokines consists of six immune mediators,
namely IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. IL-10, IL-22, IL-24 and IL-26 are critical for …
namely IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. IL-10, IL-22, IL-24 and IL-26 are critical for …
[HTML][HTML] T cell–derived IL-10 impairs host resistance to Mycobacterium tuberculosis infection
L Moreira-Teixeira, PS Redford… - The Journal of …, 2017 - journals.aai.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis infection, is a leading cause of
mortality and morbidity, causing∼ 1.5 million deaths annually. CD4+ T cells and several …
mortality and morbidity, causing∼ 1.5 million deaths annually. CD4+ T cells and several …
Airway macrophages mediate mucosal vaccine–induced trained innate immunity against Mycobacterium tuberculosis in early stages of infection
Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis (TB), is
responsible for millions of infections and deaths annually. Decades of TB vaccine …
responsible for millions of infections and deaths annually. Decades of TB vaccine …
Recent advances in the development of protein-and peptide-based subunit vaccines against tuberculosis
The World Health Organization (WHO) herald of the “End TB Strategy” has defined goals
and targets for tuberculosis prevention, care, and control to end the global tuberculosis …
and targets for tuberculosis prevention, care, and control to end the global tuberculosis …