The repair or replacement of damaged skins is still an important, challenging public health
problem. Immune acceptance and long-term survival of skin grafts represent the major …

Transplant biologists have made significant progress over the last 20 years towards
unraveling the immunologic intricacies of allograft rejection. This large body of work has …

Helminth parasites defy immune exclusion through sophisticated evasion mechanisms,
including activation of host immunosuppressive regulatory T (Treg) cells. The mouse …

Abstract Treatment with HIV-1 protease inhibitors (PI) is associated with a reduced incidence
or regression of Kaposi sarcoma (KS). Here we show that systemic administration of the PIs …

Background. Composite tissue transplantation effectively reconstructs the most complex
defects, but its use is limited because of harmful immunosuppression and the high …

Despite evidence that human non-hematopoietic cells, such as vascular endothelium, can
activate allogeneic T lymphocytes in vitro, the prevailing view has been that hematopoietic …

To prevent bystander destruction of healthy host tissues, cytotoxic CD8+ T lymphocytes are
fitted with specific receptors that direct their destructive forces specifically against chosen …

Outcomes after lung transplantation are markedly inferior to those after other solid organ
transplants. A better understanding of cellular and molecular mechanisms contributing to …

Pre-donation kidney volume and function may be crucial factors in determining graft
outcomes in kidney transplant recipients. We measured living donor kidney volumes by 3D …

Blockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in
selected rodent and in primate models, but, due to the ability of CD154-independent CD8+ T …