Potential of Essential Oil-Based Anticholinesterase Insecticides against Anopheles Vectors: A Review

TA Rants'o, LL Koekemoer, JL Panayides, RL van Zyl - Molecules, 2022 - mdpi.com
The insect nervous system is critical for its functional integrity. The cholinergic system, of
which acetylcholinesterase (AChE) is a key enzyme, is essential to the Anopheles …

Anopheles metabolic proteins in malaria transmission, prevention and control: a review

EO Adedeji, OO Ogunlana, S Fatumo, T Beder… - Parasites & vectors, 2020 - Springer
The increasing resistance to currently available insecticides in the malaria vector,
Anopheles mosquitoes, hampers their use as an effective vector control strategy for the …

Larvicidal Activity of Cinnamic Acid Derivatives: Investigating Alternative Products for Aedes aegypti L. Control

MO Araújo, Y Pérez-Castillo, LHG Oliveira, FC Nunes… - Molecules, 2020 - mdpi.com
The mosquito Aedes aegypti transmits the virus that causes dengue, yellow fever, Zika and
Chikungunya viruses, and in several regions of the planet represents a vector of great …

In vitro and in silico analysis of the Anopheles anticholinesterase activity of terpenoids

TA Rants'o, LL Koekemoer, RL van Zyl - Parasitology International, 2023 - Elsevier
Abstract Anopheles gambiae, An. coluzzii, An. arabiensis, and An. funestus are major
vectors in high malaria endemic African regions. Various terpenoid classes form the main …

Larvicidal Activity of Constituents from the Main Brazilian Propolis Types: Green, Red, and Brown against Aedes aegypti

VP Ribeiro, JK Bastos, AS Estep, KM Meepagala - ACS omega, 2024 - ACS Publications
In search of environmentally benign and mammalian-friendly mosquito-mitigating
compounds, we conducted an investigation into the constituents isolated from Brazilian red …

Enzyme Dynamics Determine the Potency and Selectivity of Inhibitors Targeting Disease-Transmitting Mosquitoes

R Kumari, C Lindgren, R Kumar, N Forsgren… - ACS Infectious …, 2024 - ACS Publications
Vector control of mosquitoes with insecticides is an important tool for preventing the spread
of mosquito-borne diseases including malaria, dengue, chikungunya, and Zika …

Discovery of novel acetylcholinesterase inhibitors by virtual screening, in vitro screening, and molecular dynamics simulations

CJ van der Westhuizen, A Stander… - Journal of Chemical …, 2022 - ACS Publications
Alzheimer's disease is the most common neurodegenerative disease and currently poses a
significant socioeconomic problem. This study describes the uses of computer-aided drug …

Synthesis of the kinase inhibitors nintedanib, hesperadin, and their analogues using the eschenmoser coupling reaction

L Marek, J Vana, J Svoboda… - The Journal of Organic …, 2021 - ACS Publications
A novel synthetic approach involving an Eschenmoser coupling reaction of substituted 3-
bromooxindoles (H, 6-Cl, 6-COOMe, 5-NO2) with two substituted thiobenzanilides in …

Structure–Activity Relationships Reveal Beneficial Selectivity Profiles of Inhibitors Targeting Acetylcholinesterase of Disease-Transmitting Mosquitoes

A Vidal-Albalat, T Kindahl, R Rajeshwari… - Journal of Medicinal …, 2023 - ACS Publications
Insecticide resistance jeopardizes the prevention of infectious diseases such as malaria and
dengue fever by vector control of disease-transmitting mosquitoes. Effective new insecticidal …

Vector Control and Insecticidal Resistance in the African Malaria Mosquito Anopheles gambiae

M Schmidt, V Hrabcova, D Jun, K Kuca… - Chemical Research in …, 2018 - ACS Publications
Mosquito-borne diseases (including malaria) belong among the leading causes of death in
humans. Vector control is a crucial part of the global strategy for management of mosquito …