The Rho subfamily members of Rho GTPases, RhoA, RhoB, and RhoC, are key regulators
of signal transduction in a variety of cellular processes, including regulation of actomyosin …

Rho GTPases, a family of the Ras GTPase superfamily, are key regulators of the actin
cytoskeleton. They were originally thought to primarily affect cell migration and invasion; …

When compared to other malignancies, the tumor microenvironment (TME) of primary and
castration-resistant prostate cancer (CRPC) is relatively devoid of immune infiltrates. While …

GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to
promote the conversion of the active GTPase-GTP form to the GTPase-GDP form. Based on …

Most cancer deaths are due to the colonization of tumor cells in distant organs. More
evidence indicates that overexpression of RACGAP1 plays a critical role in cancer …

Rho GTPases are critical signal transducers of multiple pathways. They have been
proposed to be useful anti-neoplastic targets for over two decades, especially in Ras-driven …

Cancer progression and metastasis are processes that involve significant cellular changes.
Many of these changes include alterations in the activity of the Rho GTPase family of …

Rho GTPases activated in cancer cells drive proliferation, migration, and metastasis. Thus,
RhoGAP proteins, which negatively regulate Rho GTPases, are generally thought to function …

Metastatic breast-cancer is a major cause of death in women worldwide, yet the relationship
between oncogenic drivers that promote metastatic versus primary cancer is still …

Considering the importance of microRNAs (miRNAs) in regulating cellular processes, we
performed microarray analysis and revealed miR‐4324 as one of the most differentially …