Cardiometabolic diseases are the leading cause of death worldwide. Despite a known
genetic component, our understanding of these diseases remains incomplete. Here, we …

Obesity and cardiometabolic disease often, but not always, coincide. Distinguishing
subpopulations within which cardiometabolic risk diverges from the risk expected for a given …

Mitochondria are key orchestrators of antiviral responses that serve as platforms for the
assembly and activation of innate immune-signaling complexes. In response to viral …

CRISPR base editing screens enable analysis of disease-associated variants at scale;
however, variable efficiency and precision confounds the assessment of variant-induced …

Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor
proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin …

Chronic liver diseases are commonly associated with dysregulated cholesterol metabolism.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease of the proprotein …

The majority of risk loci identified by genome-wide association studies (GWAS) are in non-
coding regions, hampering their functional interpretation. Instead, transcriptome-wide …

Rare genetic variants can have strong effects on phenotypes, yet accounting for rare
variants in genetic analyses is statistically challenging due to the limited number of allele …

Background Evidence about the association between calculated remnant cholesterol (RC)
and risk of heart failure (HF) in participants with diabetes mellitus (DM) remains sparse and …

We aimed at examining the shared and unique associations of metabolites with multiple
cardiometabolic diseases, including type 2 diabetes (T2D), coronary heart disease (CHD) …