This study reviewed aspects of the biology of two members of the glucosinolate family,
namely sinigrin and glucoraphanin and their anti-tumour and antimicrobial properties …

Drain-associated intracerebral infections are life-threatening emergencies. Their treatment is
challenging due to the limited penetration of antibiotics to the site of infection, resulting in …

This review investigated the effectiveness and safety of intrathecal (ITH) or intraventricular
(IVT) antimicrobial therapy for post-neurosurgical intracranial infection due to multidrug …

Background The emergence of multidrug-resistant pathogens has resulted in difficult-to-treat
ventriculitis/meningitis (VM). We used a meta-analysis to study the role of intraventricular …

Intraventricular or intrathecal administration of polymyxins are increasingly used to treat
multidrug-resistant (MDR) Gram-negative bacteria caused infections in the central nervous …

The treatment of Acinetobacter baumannii infections remains a challenge for physicians
worldwide in the 21st century. The bacterium possesses a multitude of mechanisms to …

Abstract On 27 August, 2018, the US Food and Drug Administration approved eravacycline,
a fluorocycline antimicrobial agent within the tetracycline class of antibacterial drugs, for the …

Objectives: Colistin has come to the fore as a treatment option, especially with the
occurrence of multidrug-resistant Gram-negative infections across the world. However, the …

Introduction Nosocomial infectious ventriculitis caused by multidrug-resistant (MDR) Gram-
negative bacilli associated with external ventricular drainage (EVD) placement poses a …

Background Hospital-acquired multidrug-resistant (MDR) bacterial meningitis and/or
ventriculitis (MEN) is a severe condition associated with high mortality. The risk factors …