Novel functions and signalling pathways for GDNF
H Sariola, M Saarma - Journal of cell science, 2003 - journals.biologists.com
Glial-cell-line-derived neurotrophic factor (GDNF) was originally identified as a survival
factor for midbrain dopaminergic neurons. GDNF and related ligands, neurturin (NRTN) …
factor for midbrain dopaminergic neurons. GDNF and related ligands, neurturin (NRTN) …
RET tyrosine kinase signaling in development and cancer
E Arighi, MG Borrello, H Sariola - Cytokine & growth factor reviews, 2005 - Elsevier
The variety of diseases caused by mutations in RET receptor tyrosine kinase provides a
classic example of phenotypic heterogeneity. Gain-of-function mutations of RET are …
classic example of phenotypic heterogeneity. Gain-of-function mutations of RET are …
RET Proto-Oncogene: A Review and Update of Genotype–Phenotype Correlations in Hereditary Medullary Thyroid Cancer and Associated Endocrine Tumors
MA Kouvaraki, SE Shapiro, ND Perrier, GJ Cote… - Thyroid, 2005 - liebertpub.com
Hereditary medullary thyroid carcinoma (MTC) is caused by autosomal dominant gain-of-
function mutations in the RET proto-oncogene. Associations between specific RET …
function mutations in the RET proto-oncogene. Associations between specific RET …
[HTML][HTML] GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease
ER Kramer, B Liss - Febs Letters, 2015 - Elsevier
Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal
together or independently to fulfill many important functions in the midbrain dopaminergic …
together or independently to fulfill many important functions in the midbrain dopaminergic …
γ-Secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney
Notch signaling is involved in pronephros development in Xenopus and in
glomerulogenesis in mice. However, owing to early lethality in mice deficient for some Notch …
glomerulogenesis in mice. However, owing to early lethality in mice deficient for some Notch …
RET and neuroendocrine tumors
M Ichihara, Y Murakumo, M Takahashi - Cancer letters, 2004 - Elsevier
Glial cell line-derived neurotrophic factor (GDNF), a ligand of RET tyrosine kinase, and its
family ligands promote the survival and differentiation of a variety of neurons. Gene ablation …
family ligands promote the survival and differentiation of a variety of neurons. Gene ablation …
Critical and distinct roles for key RET tyrosine docking sites in renal development
Molecular mechanisms that lead to congenital anomalies of kidneys and the lower urinary
tract (CAKUT) are poorly understood. To elucidate the molecular basis for signaling …
tract (CAKUT) are poorly understood. To elucidate the molecular basis for signaling …
RET and NTRK1 proto‐oncogenes in human diseases
L Alberti, C Carniti, C Miranda… - Journal of cellular …, 2003 - Wiley Online Library
RET and NTRK1 are receptor tyrosine kinase (RTK) proteins which play a role in the
development and maturation of specific component of the nervous system. Their alterations …
development and maturation of specific component of the nervous system. Their alterations …
Glial cell line‐derived neurotrophic factor‐induced signaling in Schwann cells
T Iwase, CG Jung, H Bae, M Zhang… - Journal of …, 2005 - Wiley Online Library
Glial cell line‐derived neurotrophic factor (GDNF), a known survival factor for neurons, has
recently been shown to stimulate the migration of Schwann cells (SCs) and to enhance …
recently been shown to stimulate the migration of Schwann cells (SCs) and to enhance …
Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis
The Ret receptor tyrosine kinase mediates physiological signals of glial cell line-derived
neurotrophic factor (GDNF) family ligands (GFLs) and is essential for postnatal survival in …
neurotrophic factor (GDNF) family ligands (GFLs) and is essential for postnatal survival in …