Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …

Purpose Target-based strategy is a prevalent means of drug research and development
(R&D), since targets provide effector molecules of drug action and offer the foundation of …

In the present work, the thermodynamic aspects related to the driving force of cocrystal
formation and their stability were studied for a series of 1: 1 carbamazepine (CBZ) …

Polymorphism is a common phenomenon among single-and multicomponent molecular
crystals that has a significant impact on the contemporary drug development process. A new …

Based on the importance of polymorphic regulation, the molecular mechanism of nucleation
has been widely concerned. This review begins by introducing the development and …

An anti-solvent slurry method for cocrystal formation is developed and tested in 25
carbamazepine cocrystal systems. With a low solvent/anti-solvent volume ratio, it reduces …

Staphylococcus aureus (S. aureus), commonly known as “superbugs”, is a highly
pathogenic bacterium that poses a serious threat to human health. There is an urgent need …

The first ternary cocrystals of carbamazepine (CBZ) were successfully identified through a
large-scale screening. A design strategy involved the use of an aliphatic dicarboxylic acid to …

Cocrystallization has emerged as a promising strategy to obtain new solid forms of a given
compound with tailored properties. In this study, a green and efficient slurry method was …

The dapsone/flavone cocrystal system served as a benchmark for both experimental and
virtual screening methods. Expanding beyond this, two additional active pharmaceutical …