Following the sequencing of the human genome and many other organisms, research on
protein-coding genes and their functions (functional genomics) has intensified …

This article presents an overview of the literature and a review of recent advances in the
analysis of stable and transient protein–protein interactions (PPI s) with a focus on their …

Reduction and alkylation of cysteine residues is part of virtually any proteomics workflow.
Despite its frequent use, up to date no systematic investigation of the impact of different …

Jumping translocation breakpoint (JTB) gene acts as a tumor suppressor or an oncogene in
different malignancies, including breast cancer (BC), where it was reported as …

There are only 30,000 human genes, which, according to the central dogma from biology, it
means that there should be 30,000 mRNA and 30,000 proteins. However, there are at least …

Extracellular matrix stiffness (ECM) is one of the many mechanical forces acting on
mammalian adherent cells and an important determinant of cellular function. While the effect …

The secretome includes all macromolecules secreted by cells, in particular conditions at
defined times, allowing cell–cell communication. Cancer cell secretomes that are altered …

Autism spectrum disorder (ASD) diagnosis is increasing, with 1/88 children believed to be
affected by the disorder, with a most recent survey suggesting numbers as high as 1/50 …

Obstructive sleep apnoea (OSA) affects 9–24% of the adult population. OSA is associated
with atrial disease, including atrial enlargement, fibrosis and arrhythmias. Despite the link …

The etiology and pathogenesis of many psychiatric disorders are unclear with many
signaling pathways and complex interactions still unknown. Primary information provided …