In vitro transcribed (IVT) mRNA has recently come into focus as a potential new drug class to
deliver genetic information. Such synthetic mRNA can be engineered to transiently express …

During the past decades, anticancer immunotherapy has evolved from a promising
therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now …

Dendritic-cells (DCs) have received considerable attention as potential targets for the
development of anticancer vaccines. DC-based anticancer vaccination relies on patient …

The oncofetal antigen immature laminin receptor protein (OFA-iLRP) is a highly conserved
protein that is preferentially expressed in fetal tissues and in many types of cancer, including …

Bone marrow‐derived dendritic cells (DCs) are the most potent antigen‐presenting cells
capable of activating naïve T cells. Loading DCs ex vivo with tumor antigens can stimulate …

Antigen targeted immunotherapies might represent a novel treatment for B-cell chronic
lymphocytic leukemia (B-CLL). We screened the mRNA expression of tumor-associated …

From early excitement to total disillusionment and now gaining momentum again, cancer
vaccination has been a real roller-coaster ride. Are the current expectations justified or will …

Dendritic cell (DC)-based vaccines against cancer have been extensively developed over
the past two decades. Typically DC-based cancer immunotherapy entails loading patient …

Drug resistance remains a major clinical challenge for cancer treatment. One mechanism by
which tumor cells develop resistance to cytotoxic agents and radiation is related to …

RNA is the only molecule known to recapitulate all biochemical functions of life: definition,
control and transmission of genetic information, creation of defined three-dimensional …