[HTML][HTML] m6A modification in inflammatory bowel disease provides new insights into clinical applications
J Zhang, B Song, Y Zeng, C Xu, L Gao, Y Guo… - Biomedicine & …, 2023 - Elsevier
Inflammatory bowel disease (IBD) results from a complex interplay between genetic
predisposition, environmental factors, and gut microbes. The role of N6-methyladenosine …
predisposition, environmental factors, and gut microbes. The role of N6-methyladenosine …
A novel peptide encoded by N6-methyladenosine modified circMAP3K4 prevents apoptosis in hepatocellular carcinoma
JL Duan, W Chen, JJ Xie, ML Zhang, RC Nie, H Liang… - Molecular cancer, 2022 - Springer
Abstract Background Circular RNAs (circRNAs) regulate various biological activities and
have been shown to play crucial roles in hepatocellular carcinoma (HCC) progression …
have been shown to play crucial roles in hepatocellular carcinoma (HCC) progression …
Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation
XT Lin, HQ Yu, L Fang, Y Tan, ZY Liu, D Wu, J Zhang… - Elife, 2021 - elifesciences.org
Dysregulation of tumor-relevant proteins may contribute to human hepatocellular carcinoma
(HCC) tumorigenesis. FBXO45 is an E3 ubiquitin ligase that is frequently elevated …
(HCC) tumorigenesis. FBXO45 is an E3 ubiquitin ligase that is frequently elevated …
Exploring the impact of m6A modification on immune diseases: mechanisms and therapeutic implication
Y Chen, M Liu, M Lu, L Luo, Z Han, X Liu - Frontiers in Immunology, 2024 - frontiersin.org
N6-methyladenosine (m6A) is a chemical modification of RNA and has become a widely
discussed topic among scientific researchers in recent years. It is distributed in various …
discussed topic among scientific researchers in recent years. It is distributed in various …
[HTML][HTML] RNA binding protein IGF2BP1 meditates oxidative stress-induced granulosa cell dysfunction by regulating MDM2 mRNA stability in an m6A-dependent …
H Mu, S Cai, X Wang, H Li, L Zhang, H Li, W Xiang - Redox biology, 2022 - Elsevier
Both genetic and microenvironmental detrimental factors are involved in ovarian
dysfunction, leading to the increasing rate of involuntary childlessness in recent years …
dysfunction, leading to the increasing rate of involuntary childlessness in recent years …
[HTML][HTML] Intestinal transit-amplifying cells require METTL3 for growth factor signaling and cell survival
CH Danan, KE Naughton, KE Hayer, S Vellappan… - JCI insight, 2023 - ncbi.nlm.nih.gov
Intestinal epithelial transit-amplifying cells are essential stem progenitors required for
intestinal homeostasis, but their rapid proliferation renders them vulnerable to DNA damage …
intestinal homeostasis, but their rapid proliferation renders them vulnerable to DNA damage …
Development of a specific and potent IGF2BP1 inhibitor: A promising therapeutic agent for IGF2BP1-expressing cancers
IGF2BP1 is a protein that controls the stability, localization, and translation of various mRNA
targets. Poor clinical outcomes in numerous cancer types have been associated with its …
targets. Poor clinical outcomes in numerous cancer types have been associated with its …
The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating occludin expression
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an mRNA-binding protein
that has an oncofetal pattern of expression. It is also expressed in intestinal tissue …
that has an oncofetal pattern of expression. It is also expressed in intestinal tissue …
Autophagic state prospectively identifies facultative stem cells in the intestinal epithelium
NM Johnson, LR Parham, J Na, KE Monaghan… - EMBO …, 2022 - embopress.org
The intestinal epithelium exhibits a rapid and efficient regenerative response to injury.
Emerging evidence supports a model where plasticity of differentiated cells, particularly …
Emerging evidence supports a model where plasticity of differentiated cells, particularly …
Intestinal epithelial autophagy is required for the regenerative benefit of calorie restriction
PA Williams, KE Naughton, LA Simon… - American Journal …, 2023 - journals.physiology.org
Calorie restriction can enhance the regenerative capacity of the injured intestinal epithelium.
Among other metabolic changes, calorie restriction can activate the autophagy pathway …
Among other metabolic changes, calorie restriction can activate the autophagy pathway …