Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death
worldwide. Low-density lipoprotein cholesterol (LDL-C) is a well-established mediator of …

Physical inactivity is common during periods of self-isolation, but for patients with rheumatic
diseases, there are crucial benefits to be gained from maintaining an active lifestyle …

Recent advances in human genetics, together with a large body of epidemiologic,
preclinical, and clinical trial results, provide strong support for a causal association between …

The American College of Cardiology (ACC) has a long history of developing documents (eg,
decision pathways, health policy statements, appropriate use criteria) to provide members …

Aims Loss-of-function mutations in ANGPTL3 are associated with beneficial effects on lipid
and glucose metabolism and reduced risk of coronary artery disease. Vupanorsen (AKCEA …

Scientific interest in triglyceride-rich lipoproteins has fluctuated over the past many years,
ranging from beliefs that these lipoproteins cause atherosclerotic cardiovascular disease …

Background: In time-to-first-event analyses, icosapent ethyl significantly reduced the risk of
ischemic events, including cardiovascular death, among patients with elevated triglycerides …

Background Even when low-density lipoprotein-cholesterol (LDL-C) levels are lower than
guideline thresholds, a residual risk of atherosclerosis remains. It is unknown whether …

The aim of this updated guideline is to provide comprehensive and timely evidence-based
recommendations on the prevention of future stroke among survivors of ischemic stroke or …

Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …