Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …

Epithelial-to-mesenchymal transition (EMT) is a process by which cells lose their epithelial
characteristics and gain mesenchymal phenotypes. In cancer, EMT is thought to drive tumor …

Acquired resistance to tyrosine kinase inhibitors (TKI), such as osimertinib used to treat
EGFR-mutant lung adenocarcinomas, limits long-term efficacy and is frequently caused by …

Abstract AT-Rich Interaction Domain 1A (ARID1A) is an important SWItch/Sucrose Non-
Fermentation (SWI/SNF) chromatin remodeling complex subunit, and its coding gene has a …

Simple Summary Pancreatic ductal adenocarcinoma's (PDAC) dismal prognosis is
associated with its aggressive biological behavior and resistance to chemotherapy …

ARID1A is a key mammalian SWI/SNF complex subunit that is mutated in 5% to 11% of lung
cancers. Although recent studies have elucidated the mechanism underlying dysregulation …

Gastric cancer (GC) has emerged as a significant issue in public health all worldwide as a
result of its high mortality rate and dismal prognosis. AT-rich interactive domain 1 A …

Background: Pancreatic adenocarcinoma is one of the cancers with the worst prognosis.
The current treatment paradigm based on combination chemotherapy has improved survival …

Objective. Hepatocellular carcinoma (HCC) is one of the most lethal malignancies with a
poor prognosis. The AT‐rich interaction domain (ARID) family plays an essential regulatory …

The switch/sucrose non-fermentable (SWI/SNF)(SWI/SNF) complex uses energy from ATP
hydrolysis to mobilise nucleosomes on chromatin. Components of SWI/SNF are mutated in …