Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

The phosphoenolpyruvate (PEP): carbohydrate phosphotransferase system (PTS) is found
only in bacteria, where it catalyzes the transport and phosphorylation of numerous …

Carbon catabolite repression (CCR) in bacteria is generally regarded as a regulatory
mechanism to ensure sequential utilization of carbohydrates. Selection of the carbon …

Application of metabolic engineering principles to the rational design of microbial production
processes crucially depends on the ability to describe quantitatively the systemic behavior of …

Carbon catabolite repression (CCR) is a regulatory mechanism by which the expression of
genes required for the utilization of secondary sources of carbon is prevented by the …

Escherichia coli growing on glucose in minimal medium controls its metabolite pools in
response to environmental conditions. The extent of pool changes was followed through two …

Availability of carbon/energy sources and temperature are the two environmental factors that
severely restrict heterotrophic growth in most ecosystems. DOC concentrations in ground …

We followed 68 cellular metabolites after carbon or nitrogen starvation of Escherichia coli
and Saccharomyces cerevisiae, using a filter-culture methodology that allows exponential …

Despite our increasing topological knowledge on regulation networks in model bacteria, it is
largely unknown which of the many co‐occurring regulatory events actually control …

The rational improvement of microbial strains for the production of primary and secondary
metabolites ('metabolic engineering') requires a quantitative understanding of microbial …