Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Physical forces regulate numerous biological processes during development, physiology,
and pathology. Forces between the external environment and intracellular actin cytoskeleton …

Extracellular matrix (ECM) rigidity serves as a crucial mechanical cue impacting diverse
biological processes. However, understanding the molecular mechanisms of rigidity sensing …

The Arp2/3 complex orchestrates the formation of branched actin networks at the interface
between the cytoplasm and membranes. Although it is widely appreciated that these …

Integrin adhesions are a structurally and functionally diverse family of transmembrane, multi-
protein complexes that link the intracellular cytoskeleton to the extracellular matrix (ECM) …

Phagocytosis requires rapid actin reorganization and spatially controlled force generation to
ingest targets ranging from pathogens to apoptotic cells. How actomyosin activity directs …

Podosomes are dynamic adhesion structures formed constitutively by macrophages,
dendritic cells and osteoclasts and transiently in a wide variety of cells, such as endothelial …

In solid tumours, cancer cells that undergo epithelial mesenchymal transition (EMT) express
characteristic gene expression signatures that promote invasive migration as well as the …