Bronchiolitis

SR Dalziel, L Haskell, S O'Brien, ML Borland, AC Plint… - The Lancet, 2022 - thelancet.com
Viral bronchiolitis is the most common cause of admission to hospital for infants in high-
income countries. Respiratory syncytial virus accounts for 60–80% of bronchiolitis …

Innate and adaptive immunity during SARS-CoV-2 infection: biomolecular cellular markers and mechanisms

B Brown, V Ojha, I Fricke, SA Al-Sheboul, C Imarogbe… - Vaccines, 2023 - mdpi.com
The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-
stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Dupilumab in persistent asthma with elevated eosinophil levels

S Wenzel, L Ford, D Pearlman, S Spector… - New England journal …, 2013 - Mass Medical Soc
Background Moderate-to-severe asthma remains poorly treated. We evaluated the efficacy
and safety of dupilumab (SAR231893/REGN668), a fully human monoclonal antibody to the …

Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants

X Yang, X Liu, Y Nie, F Zhan, B Zhu - Virology Journal, 2023 - Springer
Respiratory syncytial virus (RSV), a member of the Pneumoviridae family, can cause severe
acute lower respiratory tract infection in infants, young children, immunocompromised …

Involvement of Il-33 in the pathogenesis and prognosis of major respiratory viral infections: future perspectives for personalized therapy

G Murdaca, F Paladin, A Tonacci, M Borro, M Greco… - Biomedicines, 2022 - mdpi.com
Interleukin (IL)-33 is a key cytokine involved in type-2 immunity and allergic airway disease.
At the level of lung epithelial cells, where it is clearly expressed, IL-33 plays an important …

Alarmins and innate lymphoid cells 2 activation: A common pathogenetic link connecting respiratory syncytial virus bronchiolitis and later wheezing/asthma?

GA Rossi, S Ballarini, P Salvati… - Pediatric Allergy and …, 2022 - Wiley Online Library
Severe respiratory syncytial virus (RSV) infection in infancy is associated with increased risk
of recurrent wheezing in childhood. Both acute and long‐term alterations in airway functions …

Influence of SARS-CoV-2 on airway mucus production: A review and proposed model

DK Meyerholz, LR Reznikov - Veterinary pathology, 2022 - journals.sagepub.com
Coronavirus disease 2019 (COVID-19) is a worldwide pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) that has affected millions of lives …

The matrix protein of respiratory syncytial virus suppresses interferon signaling via RACK1 association

J Cao, M Shi, L Zhu, X Li, A Li, SY Wu… - Journal of …, 2023 - Am Soc Microbiol
Respiratory syncytial virus (RSV) is a frequent cause of respiratory illness among pediatric
and elderly populations. The severity of the respiratory disease is determined, in part, by …

Interferons as negative regulators of ILC2s in allergic lung inflammation and respiratory viral infections

C Wang, Z Du, R Li, Y Luo, C Zhu, N Ding… - Journal of Molecular …, 2023 - Springer
Group 2 innate lymphoid cells (ILC2s), characterized by a lack of antigen receptors, have
been regarded as an important component of type 2 pulmonary immunity. Analogous to Th2 …

Respiratory syncytial virus infection induces chromatin remodeling to activate growth factor and extracellular matrix secretion pathways

X Xu, D Qiao, M Mann, RP Garofalo, AR Brasier - Viruses, 2020 - mdpi.com
Lower respiratory tract infection (LRTI) with respiratory syncytial virus (RSV) is associated
with reduced lung function through unclear mechanisms. In this study, we test the hypothesis …