Mammalian sperm cells must respond to cues originating from along the female
reproductive tract and from the layers of the egg in order to complete their fertilization …

A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

In the oviduct, cumulus cells that surround the oocyte release progesterone. In human
sperm, progesterone stimulates a Ca2+ increase by a non-genomic mechanism,,. The Ca2+ …

Testicular spermatozoa acquire fertility only after 1 or 2 weeks of transit through the
epididymis. At the end of this several meters long epididymal tubule, the male gamete is …

BACKGROUND Sperm hyperactivation is critical to fertilization, because it is required for
penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from …

Sexually reproducing animals require an orchestrated communication between
spermatozoa and the egg to generate a new individual. Capacitation, a maturational …

Ion channels control the sperm ability to fertilize the egg by regulating sperm maturation in
the female reproductive tract and by triggering key sperm physiological responses required …

Mammalian sperm must undergo a series of biochemical and physiological modifications,
collectively called capacitation, in the female reproductive tract prior to the acrosome …

In mammals, fertilization occurs via a comprehensive progression of events. Freshly
ejaculated sperm have yet to acquire progressive motility or fertilization ability. They must …

The Catsper channel is a sperm-specific, Ca 2+-permeable, pH-dependent, and low voltage-
dependent channel that is essential for the hyperactivity of sperm flagellum, chemotaxis …