Microfluidic organs-on-chips
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …
methods that contains continuously perfused chambers inhabited by living cells arranged to …
[HTML][HTML] Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing
U Marx, TB Andersson, A Bahinski, M Beilmann… - Altex, 2016 - ncbi.nlm.nih.gov
The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
In vivo–mimicking microfluidic perfusion culture of pancreatic islet spheroids
Native pancreatic islets interact with neighboring cells by establishing three-dimensional
(3D) structures, and are surrounded by perfusion at an interstitial flow level. However, flow …
(3D) structures, and are surrounded by perfusion at an interstitial flow level. However, flow …
Tissue chips–innovative tools for drug development and disease modeling
LA Low, DA Tagle - Lab on a Chip, 2017 - pubs.rsc.org
The high rate of failure during drug development is well-known, however recent advances in
tissue engineering and microfabrication have contributed to the development of …
tissue engineering and microfabrication have contributed to the development of …
Microfluidic organ/body-on-a-chip devices at the convergence of biology and microengineering
Recent advances in biomedical technologies are mostly related to the convergence of
biology with microengineering. For instance, microfluidic devices are now commonly found …
biology with microengineering. For instance, microfluidic devices are now commonly found …
Modelling the endocrine pancreas in health and disease
Diabetes mellitus is a multifactorial disease affecting increasing numbers of patients
worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss …
worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss …
Type 1 Diabetes Mellitus: A Review on Advances and Challenges in Creating Insulin Producing Devices
SM Rodrigues Oliveira, A Rebocho, E Ahmadpour… - Micromachines, 2023 - mdpi.com
Type 1 diabetes mellitus (T1DM) is the most common autoimmune chronic disease in young
patients. It is caused by the destruction of pancreatic endocrine β-cells that produce insulin …
patients. It is caused by the destruction of pancreatic endocrine β-cells that produce insulin …
Synchronized stimulation and continuous insulin sensing in a microfluidic human Islet on a Chip designed for scalable manufacturing
Pancreatic β cell function is compromised in diabetes and is typically assessed by
measuring insulin secretion during glucose stimulation. Traditionally, measurement of …
measuring insulin secretion during glucose stimulation. Traditionally, measurement of …
3D printing of scaffold for cells delivery: advances in skin tissue engineering
Injury or damage to tissue and organs is a major health problem, resulting in about half of
the world's annual healthcare expenditure every year. Advances in the fields of stem cells …
the world's annual healthcare expenditure every year. Advances in the fields of stem cells …
3-D physiomimetic extracellular matrix hydrogels provide a supportive microenvironment for rodent and human islet culture
Organ-on-a-chip platforms serve as cost-efficient testbeds for screening pharmaceutical
agents, mimicking natural physiology, and studying disease. In the field of diabetes, the …
agents, mimicking natural physiology, and studying disease. In the field of diabetes, the …