Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery

T Burnouf, ML Chou, DJ Lundy, EY Chuang… - Journal of Biomedical …, 2023 - Springer
Platelets are small anucleated blood cells primarily known for their vital hemostatic role.
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …

Production and quality requirements of human platelet lysate: a position statement from the working party on cellular therapies of the international society of blood …

K Schallmoser, R Henschler, C Gabriel, MBC Koh… - Trends in …, 2020 - cell.com
Human platelet lysate (HPL), rich in growth factors, is an efficient alternative supplement to
fetal bovine serum (FBS) for ex vivo propagation of stromal cell-based medicinal products …

Platelet‐rich fibrin elicits an anti‐inflammatory response in macrophages in vitro

J Nasirzade, Z Kargarpour, S Hasannia… - Journal of …, 2020 - Wiley Online Library
Background Platelet‐rich fibrin (PRF) serves as a reservoir of bioactive molecules to support
wound healing and bone regeneration. The beneficial action of PRF might involve …

Intelligent micro-/nanorobots as drug and cell carrier devices for biomedical therapeutic advancement: Promising development opportunities and translational …

V Agrahari, V Agrahari, ML Chou, CH Chew, J Noll… - Biomaterials, 2020 - Elsevier
Nanotechnology and microfabrication approaches are playing instrumental roles in the
development of innovative technologies to fight human diseases. Because of promising in …

The effectiveness and safety of platelet-rich plasma for chronic wounds: A systematic review and meta-analysis

W Qu, Z Wang, C Hunt, AS Morrow, M Urtecho… - Mayo Clinic …, 2021 - Elsevier
Objective To evaluate the effectiveness and adverse events of autologous platelet-rich
plasma (PRP) in individuals with lower-extremity diabetic ulcers, lower-extremity venous …

Men and women differ in the biochemical composition of platelet-rich plasma

G Xiong, N Lingampalli, JCB Koltsov… - … American journal of …, 2018 - journals.sagepub.com
Background: Autologous platelet-rich plasma (PRP) is widely used for a variety of clinical
applications. However, clinical outcome studies have not consistently shown positive effects …

A 3D-printed biphasic calcium phosphate scaffold loaded with platelet lysate/gelatin methacrylate to promote vascularization

G Liu, B Zhang, T Wan, C Zhou, Y Fan… - Journal of Materials …, 2022 - pubs.rsc.org
3D-printed biphasic calcium phosphate (BCP) scaffolds show great clinical application
potential in bone tissue engineering; however, vascularization of the scaffold is a crucial …

Platelet lysates from aged donors promote human tenocyte proliferation and migration in a concentration-dependent manner

DR Berger, CJ Centeno, NJ Steinmetz - Bone & Joint Research, 2019 - boneandjoint.org.uk
Objectives Platelet-rich plasma (PRP) is being used increasingly often in the clinical setting
to treat tendon-related pathologies. Yet the optimal PRP preparations to promote tendon …

Novel therapeutic approaches in utilizing platelet lysate in regenerative medicine: Are we ready for clinical use?

M Zamani, Y Yaghoubi… - Journal of cellular …, 2019 - Wiley Online Library
Hemoderivative materials are used to treat different diseases. These derivatives include
platelet‐rich plasma, serum, platelet gel, and platelet lysate (PL). Among them, PL contains …

Positive impact of Platelet-rich plasma and Platelet-rich fibrin on viability, migration and proliferation of osteoblasts and fibroblasts treated with zoledronic acid

D Steller, N Herbst, R Pries, D Juhl, SG Hakim - Scientific Reports, 2019 - nature.com
Bisphosphonates are frequently used for the antiresorptive treatment in bone metastasis
diseases or for osteoporosis. A side effect of this therapy is osteonecrosis of the jaw. This …