One of the main engines that drives cellular transformation is the loss of proper control of the
mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as …

Cell cycle progression is controlled by the cyclindependent kinases (CDKs). CDKs are the
catalytic partners of the cyclins [reviewed in 1]. Regulators of G1 progression in mammalian …

Relative quiescence is a defining characteristic of hematopoietic stem cells, while their
progeny have dramatic proliferative ability and inexorably move toward terminal …

The association of cdk4 with D-type cyclins to form functional kinase complexes is
comparatively inefficient. This has led to the suggestion that assembly might be a regulated …

The protein kinase Akt is activated by growth factors and promotes cell survival and cell
cycle progression. Here, we demonstrate that Akt phosphorylates the cell cycle inhibitory …

c-Kit is a receptor tyrosine kinase that binds stem cell factor (SCF). Structurally, c-Kit contains
five immunoglobulin-like domains extracellularly and a catalytic domain divided into two …

Kit is a receptor tyrosine kinase (RTK) that binds stem cell factor. This receptor ligand
combination is important for normal hematopoiesis, as well as pigmentation, gut function …

Sustained blood cell production requires preservation of a quiescent, multipotential stem cell
pool that intermittently gives rise to progenitors with robust proliferative potential. The ability …

Clinical studies involving patients with myelodysplastic syndromes or multiple myeloma
have shown the efficacy of lenalidomide by reducing and often eliminating malignant cells …

Accumulating evidence including studies of AHR-deficient mice and TCDD toxicity suggests
multiple physiologic AHR functions. Challenges to identify responsible mechanisms are due …