Molecular mechanisms in thioacetamide-induced acute and chronic liver injury models

D Ezhilarasan - Environmental Toxicology and Pharmacology, 2023 - Elsevier
Thioacetamide (TAA) undergoes bioactivation in the liver by the CYP450 2E1 enzyme,
resulting in the formation of TAA-S-oxide and TAA-S-dioxide. TAA-S-dioxide induces …

Functional role of monocytes and macrophages for the inflammatory response in acute liver injury

HW Zimmermann, C Trautwein, F Tacke - Frontiers in physiology, 2012 - frontiersin.org
Different etiologies such as drug toxicity, acute viral hepatitis B, or acetaminophen poisoning
can cause acute liver injury or even acute liver failure (ALF). Excessive cell death of …

Curcumin, Silybin Phytosome® and α‐R‐Lipoic Acid Mitigate Chronic Hepatitis in Rat by Inhibiting Oxidative Stress and Inflammatory Cytokines Production

SO Ali, HA Darwish, NA Ismail - Basic & Clinical Pharmacology …, 2016 - Wiley Online Library
Chronic hepatitis is recognized as a worldwide health problem that gradually progresses
towards cirrhosis and hepatocellular carcinoma. Despite the large number of experiments …

[HTML][HTML] Albiflorin ameliorates thioacetamide-induced hepatic fibrosis: The involvement of NURR1-mediated inflammatory signaling cascades in hepatic stellate cells …

J Song, BF Qin, QY Feng, JJ Zhang, GY Zhao… - Ecotoxicology and …, 2024 - Elsevier
Thioacetamide (TAA) within the liver generates hepatotoxic metabolites that can be induce
hepatic fibrosis, similar to the clinical pathological features of chronic human liver disease …

[HTML][HTML] Modulatory effect of Prosopis juliflora leaves on hepatic fibrogenic and fibrolytic alterations induced in rats by thioacetamide

SM Hassan, ASM Taha, OA Eldahshan… - Biomedicine & …, 2019 - Elsevier
This study investigated the antifibrotic effect of Prosopis juliflora leaves crude methanolic
extract (PJEL) against thioacetamide (TAA)-induced liver fibrosis. The phytochemical …

Curative effect of Amorphophallus campanulatus (Roxb.) Blume. tuber methanolic extract against thioacetamide induced oxidative stress in experimental rats

PN Ansil, SP Prabha, A Nitha, PJ Wills, V Jazaira… - Asian Pacific Journal of …, 2012 - Elsevier
Objective To evaluate the curative effect of the methanolic extract of Amorphophallus
campanulatus (A. campanulatus) tuber (ACME) against thioacetamide induced oxidative …

Preventive and curative effect of Woodfordia fruticosa Kurz flowers on thioacetamide induced oxidative stress in rats

A Nitha, PN Ansil, SP Prabha, PJ Wills… - Asian Pacific Journal of …, 2012 - Elsevier
Objective To evaluate the preventive and curative effect of Woodfordia fruticosa (W.
fruticosa) Kurz flowers on thioacetamide induced oxidative stress in rats. Methods Two …

[HTML][HTML] Chemical composition and hepatotoxic effect of Geranium schiedeanum in a thioacetamide-induced liver injury model

J Gayosso-De-Lucio, M Bautista… - Pharmacognosy …, 2014 - ncbi.nlm.nih.gov
One of the major components of some geraniums is geraniin, described by its discoverer as
crystallizable tannin, well known as an excellent antioxidant, and also found in fruits such as …

[PDF][PDF] Nori-and sea spaghetti-but not wakame-restructured pork decrease the hypercholesterolemic and liver proapototic short-term effects of high-dietary cholesterol …

ARS Moreira, J Benedi, S Bastida… - Nutricion …, 2013 - redalyc.org
La incorporación de algas, ricas en fibra y compuestos asociados, a reestructurados de
carne de cerdo (R) resulta en derivados cárnicos potencialmente funcionales. En este …

Role of Kupffer cells in thioacetamide-induced cell cycle dysfunction

M Bautista, D Andres, M Cascales… - Molecules, 2011 - mdpi.com
It is well known that gadolinium chloride (GD) attenuates drug-induced hepatotoxicity by
selectively inactivating Kupffer cells. In the present study the effect of GD in reference to cell …