Organoids are three-dimensional (3D) cultures, normally derived from stem cells, that
replicate the complex structure and function of human tissues. They offer a physiologically …

Cancer progression is significantly influenced by the complex interactions within the tumor
microenvironment (TME). Immune cells, in particular, play a critical role by infiltrating tumors …

Three-dimensional (3D) cell culture has revolutionized life sciences, particularly in organoid
technologies. Traditional bioscaffold materials, however, complicate the detachment of …

The in-vivo non-human primate animal and in-vitro cell disease models play a crucial part in
the study of the mechanisms underlying the occurrence and development of pancreatic …

Pancreatic cancer is one of the most lethal cancers, with a 5-year overall survival rate of less
than 10%. Despite the development of novel therapies in recent decades, current …

Organoid biochips can replicate the micro-environment and functional traits of human
organs in vitro, reflecting the physiological and pathological features of the human body. It …

Patient-derived organoids (PDOs) serve as invaluable 3D tumor models, retaining the
histological complexity and genetic heterogeneity found in primary tumors. However, the …

The cancer‐immunity cycle is a fundamental framework for understanding how the immune
system interacts with cancer cells, balancing T cell recognition and elimination of tumors …

Since hepatic cancer incidence and mortality continue to grow worldwide, it is necessary to
develop the biomimetic tumor models for drug development and tumor therapeutics. Cellular …

Tumor organoids have emerged as powerful tools for in vitro cancer research due to their
ability to retain the structural and genetic characteristics of tumors. Nevertheless, the …