The hallmark of acquired immunodeficiency syndrome (AIDS) pathogenesis is a progressive
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …

Systemic chronic immune activation is considered today as the driving force of CD 4+ T‐cell
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …

Combination antiretroviral therapy (cART) reduces HIV-associated morbidities and
mortalities but cannot cure the infection. Given the difficulty of eradicating HIV-1, a functional …

In pathogenic simian immunodeficiency virus (SIV) and human immunodeficiency virus
(HIV) infections, the translocation of microbial products from the gastrointestinal (GI) tract to …

Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely
defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells …

The difficulty in detecting rare infected cells immediately after mucosal HIV transmission has
hindered our understanding of the initial cells targeted by the virus. Working with the …

Many species of African nonhuman primates are naturally infected with simian
immunodeficiency viruses (SIVs) in the wild and in captivity. In contrast to HIV-infected …

HIV elite controllers maintain a population of CD4+ T cells endowed with high avidity for Gag
antigens and potent effector functions. How these HIV-specific cells avoid infection and …

A genital inflammatory profile contributes to the high risk of HIV acquisition in African
women. STIs and bacterial vaginosis are poorly managed in Africa and other developing …

While CD4+ T cell depletion is key to disease progression in people living with HIV and SIV-
infected macaques, the mechanisms underlying this depletion remain incompletely …