The rise in popularity of two-photon polymerization (TPP) as an additive manufacturing
technique has impacted many areas of science and engineering, particularly those related …

Liver fibrosis is assessed mainly by conventional staining or second harmonic generation
(SHG) microscopy, which can only provide collagen content in fibrotic area. We propose to …

Second harmonic generation (SHG) microscopy is widely used to image collagen fiber
microarchitecture due to its high spatial resolution, optical sectioning capabilities and …

Bone is a unique biological composite material made up of a highly structured collagen
mesh matrix and mineral deposits. Although mineral provides stiffness, collagen's secondary …

The structural and mechanical properties of tissue and the interplay between them play a
critical role in tissue function. We introduce the optomechanogram, a combined quantitative …

Many musculoskeletal tissues are composed primarily of type I collagen, which takes on a
periodic crimp morphology that allows large tensile strains in the tissue. The spatial period of …

Collagen fibers in biological tissues have a complex 3D organization containing rich
information linked to tissue mechanical properties and are affected by mutations that lead to …

It is widely accepted that the nonlinear macroscopic mechanical behavior of soft tissue is
governed by fiber straightening and re-orientation. Here, we provide a quantitative …

This study investigates the structural and mechanical changes in uterine collagen following
exposure to propylparaben (PP) using a combined methodology of Second Harmonic …

Nonlinear microscopy has enabled additional modalities for chemical contrast, deep
penetration into biological tissues, and the ability to collect dynamics on ultrafast timescales …