Malaria vaccines: a new era of prevention and control

PE Duffy, JP Gorres, SA Healy, M Fried - Nature Reviews Microbiology, 2024 - nature.com
Malaria killed over 600,000 people in 2022, a death toll that has not improved since 2015.
Additionally, parasites and mosquitoes resistant to existing interventions are spreading …

Sex differences in tuberculosis

D Hertz, B Schneider - Seminars in immunopathology, 2019 - Springer
Tuberculosis is the most prevalent bacterial infectious disease in humans and the leading
cause of death from a single infectious agent, ranking above HIV/AIDS. The causative agent …

Safety and immunogenicity of Pfs25H-EPA/Alhydrogel, a transmission-blocking vaccine against Plasmodium falciparum: a randomised, double-blind, comparator …

I Sagara, SA Healy, MH Assadou… - The Lancet Infectious …, 2018 - thelancet.com
Summary Background Pfs25H-EPA is a protein-protein conjugate transmission-blocking
vaccine against Plasmodium falciparum that is safe and induces functional antibodies in …

Safety and efficacy of PfSPZ Vaccine against malaria in healthy adults and women anticipating pregnancy in Mali: two randomised, double-blind, placebo-controlled …

H Diawara, SA Healy, A Mwakingwe-Omari… - The Lancet Infectious …, 2024 - thelancet.com
Background Plasmodium falciparum parasitaemia during pregnancy causes maternal, fetal,
and infant mortality. Poor pregnancy outcomes are related to blood-stage parasite …

Protozoan co-infections and parasite influence on the efficacy of vaccines against bacterial and viral pathogens

L Akoolo, SC Rocha, N Parveen - Frontiers in Microbiology, 2022 - frontiersin.org
A wide range of protozoan pathogens either transmitted by vectors (Plasmodium, Babesia,
Leishmania and Trypanosoma), by contaminated food or water (Entamoeba and Giardia), or …

Uninfected but not unaffected: chronic maternal infections during pregnancy, fetal immunity, and susceptibility to postnatal infections

N Dauby, T Goetghebuer, TR Kollmann… - The Lancet infectious …, 2012 - thelancet.com
Chronic infections during pregnancy are highly prevalent in some parts of the world.
Infections with helminths, Trypanosoma cruzi, Plasmodium spp, and HIV might affect the …

Interferon-driven deletion of antiviral B cells at the onset of chronic infection

B Fallet, K Narr, YI Ertuna, M Remy… - Science …, 2016 - science.org
Inadequate antibody responses and perturbed B cell compartments represent hallmarks of
persistent microbial infections, but the mechanisms whereby persisting pathogens suppress …

The association between malaria and non-typhoid Salmonella bacteraemia in children in sub-Saharan Africa: a literature review

EN Takem, A Roca, A Cunnington - Malaria journal, 2014 - Springer
Plasmodium falciparum malaria and non-typhoid Salmonella (NTS) bacteraemia are both
major causes of morbidity and mortality in children in sub-Saharan Africa. Co-infections are …

[HTML][HTML] B cell profiling in malaria reveals expansion and remodeling of CD11c+ B cell subsets

C Sundling, C Rönnberg, V Yman, M Asghar… - JCI insight, 2019 - ncbi.nlm.nih.gov
Humoral immunity is important in limiting clinical disease in malaria, yet the longitudinal B
cell response to infection remains unclear. We performed a 1-year prospective study in …

[HTML][HTML] Chronic bystander infections and immunity to unrelated antigens

E Stelekati, EJ Wherry - Cell host & microbe, 2012 - cell.com
Chronic infections with persistent pathogens such as helminths, mycobacteria, Plasmodium,
and hepatitis viruses affect more than a third of the human population and are associated …