Abstract Type 2 diabetes (T2D) is a widely prevalent disease with substantial economic and
social impact for which multiple conventional and novel pharmacotherapies are currently …

SGLT2 (sodium-glucose cotransporter 2) enables glucose and sodium reabsorption in the
kidney. SGLT2-inhibitors (also known as gliflozins, which include canagliflozin …

Background The inflammatory response occurring in acute myocardial infarction (AMI) has
been proposed as a potential pharmacological target. Sodium-glucose co-transporter 2 …

OBJECTIVE To assess whether the sodium–glucose cotransporter 2 (SGLT2) inhibitor
empagliflozin improves cognitive impairment in frail older adults with diabetes and heart …

Endothelial dysfunction represents a key mechanism underlying heart failure with preserved
ejection fraction (HFpEF), diabetes mellitus (DM), and frailty. However, reliable biomarkers …

Restenosis, defined as the re-narrowing of an arterial lumen after revascularization,
represents an increasingly important issue in clinical practice. Indeed, as the number of stent …

Abstract L-Arginine (L-Arg), is a semi-essential amino acid involved in the formation of nitric
oxide. The functional relevance of L-Arg in diabetes mellitus has been evaluated both in …

Introduction While type 2 diabetes mellitus (T2DM) increases the risk of cardiac
complications, diabetes treatment choices may increase or decrease the rates of cardiac …

OBJECTIVE Ischemia with nonobstructive coronary arteries (INOCA) is a prevailing finding
in patients with angina. However, the main factors underlying the risk of being rehospitalized …

Diabetic cardiomyopathy (DCM), as a common complication of diabetes, is characterized by
chronic low-grade inflammation. The NLRP3 inflammasome is a key sensor mediating …