Canonical WNT/β-catenin signaling is involved in most of the mechanisms that lead to the
formation and development of cancer cells. It plays a central role in three cyclic processes …

Circadian rhythms govern a large array of physiological and metabolic functions.
Perturbations of the daily cycle have been linked to elevated risk of developing cancer as …

Abstract Background N6-methyladenosine (m6A) is the most abundant reversible
methylation modification of eukaryotic mRNA, and it plays vital roles in tumourigenesis. This …

Circadian rhythms show universally a 24-h oscillation pattern in metabolic, physiological
and behavioral functions of almost all species. This pattern is due to a fundamental …

Significance: Oxygen and circadian rhythmicity are essential in a myriad of physiological
processes to maintain homeostasis, from blood pressure and sleep/wake cycles, down to …

Most aspects of mammalian function display circadian rhythms driven by an endogenous
clock. The circadian clock is operated by genes and comprises a central clock in the brain …

Disruption of the cellular pathway modulating endogenous 24-h rhythms, referred to as “the
circadian clock”, has been recently proven to be associated with cancer risk, development …

The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology
in virtually all cells. Disruption of the genes necessary for the circadian clock to function has …

Abstract Voltage-gated Na+ channels (VGSCs) are heteromeric membrane protein
complexes containing pore-forming α subunits and smaller, non-pore-forming β subunits …

The circadian clock is a biological mechanism that dictates an array of rhythmic
physiological processes. Virtually all cells contain a functional clock whose disruption results …