With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

This review summarizes our current understanding of translation in prokaryotes, focusing on
the mechanistic and structural aspects of each phase of translation: initiation, elongation …

Recent advances in single-particle cryoelecton microscopy (cryo-EM) are enabling
generation of numerous near-atomic resolution structures for well-ordered protein …

The high-resolution structures of ribosomal subunits published in 2000 have revolutionized
the field of protein translation. They facilitated the determination and interpretation of …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

We describe two structures of the intact bacterial ribosome from Escherichia coli determined
to a resolution of 3.5 angstroms by x-ray crystallography. These structures provide a detailed …

▪ Abstract Great advances have been made in the past three decades in understanding the
molecular mechanics underlying protein synthesis in bacteria, but our understanding of the …

During the ribosomal translocation, the binding of elongation factor G (EF-G) to the
pretranslocational ribosome leads to a ratchet-like rotation of the 30S subunit relative to the …

The faithful and rapid translation of genetic information into peptide sequences is an
indispensable property of the ribosome. The mechanistic understanding of strategies used …

An 11.7‐Å‐resolution cryo‐EM map of the yeast 80S· eEF2 complex in the presence of the
antibiotic sordarin was interpreted in molecular terms, revealing large conformational …