CDH1, as a tumor suppressor gene, contributes sporadic breast cancer (BC) progression.
However, the association between CDH1 hypermethylation and BC, and its …

Summary E-cadherin (ECAD) immunohistochemical (IHC) expression is lost in∼ 90% of
invasive lobular carcinomas (ILCs) owing to genomic alterations of CDH1. We examined …

Abnormal DNA methylation is known as playing an important role in the tumorgenesis. It is
helpful for distinguishing the specificity of diagnosis and therapeutic targets for cancers …

Background: Cancer is a global medical challenge, and research is at its peak to understand
the unique mechanisms of cancer cells. The expanding field of epidemiology, including …

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors with poor
prognosis and recurrence in South China. The hard eradication of NPC in clinic is …

Pharmacogenomic studies play a significant role in understanding the risk of breast cancer
where genetic abnormalities are implicated as the etiology of cancer. Various …

Breast cancer is among the most frequently diagnosed cancer types and the leading cause
of cancer‑related death in women. The mortality rate of patients with breast cancer is …

Blood methylated cell-free DNA (cfDNA) as a minimally invasive cancer biomarker has great
importance in cancer management. Guanylate binding protein 2 (GBP2) has been …

The aim of this study was to evaluate the association between pretreatment molecular and
clinical factors and axillary lymph node metastases in early breast cancer. A total of 367 …

Background: Treatment for breast cancer is mainly performed by surgical resection of
primary tumors and chemotherapy. However, after tumor invasion and metastases, breast …