Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives

NR Srinivas - Xenobiotica, 2010 - Taylor & Francis
Baicalin was extensively researched for utility in a number of therapeutic areas owing to its
anti-inflammatory, anti-oxidant, anti-bacterial, and anti-cancer properties. A number of …

Biological analysis of herbal medicines used for the treatment of liver diseases

CF Chien, YT Wu, TH Tsai - Biomedical Chromatography, 2011 - Wiley Online Library
Herbal medicines have been used to treat liver disorders for thousands of years in the East
and have now become a promising therapy internationally for pathological liver conditions …

An in vivo analysis of the therapeutic and synergistic properties of Chinese medicinal formula Yin-Chen-Hao-Tang based on its active constituents

A Zhang, H Sun, Y Yuan, W Sun, G Jiao, X Wang - Fitoterapia, 2011 - Elsevier
6, 7-Dimethylesculetin (D), geniposide (G) and rhein (R) are the three major active
ingredients of Yin-Chen-Hao-Tang (YCHT), a famous Chinese herbal formula, which has …

Anti-inflammatory effects and pharmacokinetics study of geniposide on rats with adjuvant arthritis

JY Chen, H Wu, H Li, SL Hu, M Dai, J Chen - International …, 2015 - Elsevier
The aim of this study was to explore the anti-inflammatory effects of Geniposide (GE), an
iridoid glycoside compound extracted from Gardenia jasminoides Ellis (GJ) fruit in adjuvant …

Metabolite profiling of plasma and urine from rats with TNBS‐induced acute colitis using UPLC‐ESI‐QTOF‐MS‐based metabonomics–a pilot study

X Zhang, FFK Choi, Y Zhou, FP Leung, S Tan… - The FEBS …, 2012 - Wiley Online Library
The incidence of inflammatory bowel disease, a relapsing intestinal condition whose precise
etiology is still unclear, has continually increased over recent years. Metabolic profiling is an …

Determination of baicalin in rat cerebrospinal fluid and blood using microdialysis coupled with ultra-performance liquid chromatography-tandem mass spectrometry

H Huang, Y Zhang, R Yang, X Tang - Journal of Chromatography B, 2008 - Elsevier
An in vivo microdialysis sampling method coupled with ultra-performance liquid
chromatography-tandem mass spectrometry (UPLC-MS/MS) was employed for continuous …

Determination of bile acids in human serum by on-line restricted access material–ultra high-performance liquid chromatography–mass spectrometry

K Bentayeb, R Batlle, C Sanchez, C Nerin… - … of Chromatography B, 2008 - Elsevier
This paper describes a new, fully automated on-line method combining restricted access
material (RAM) extraction and ultra high-performance liquid chromatography (UHPLC) with …

Neuroprotective effects of TongLuoJiuNao in neurons exposed to oxygen and glucose deprivation

XJ Li, JC Hou, P Sun, PT Li, RQ He, Y Liu… - Journal of …, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: TongLuoJiuNao (TLJN) is an herb extract that
mainly contains ginsenoside Rg1 and geniposide, which are clinically used for treating …

Simultaneous determination of two iridoid glycosides, two anthraquinones and four flavonoid glycosides of Zhi-Zi-Da-Huang decoction in rat plasma by UFLC-MS/MS …

H Zhu, K Bi, F Han, J Guan, Z Tang, K Chen… - … of Chromatography B, 2014 - Elsevier
A selective, sensitive and reliable ultra fast liquid chromatography-tandem mass
spectrometry (UFLC-MS/MS) method has been developed for the simultaneous …

Using orthogonal array to obtain gradient liquid chromatography conditions of enhanced peak intensity to determine geniposide and genipin with electrospray tandem …

SC Wang, HJ Liao, WC Lee, CM Huang… - … of Chromatography A, 2008 - Elsevier
The conditions to determine geniposide and genipin using gradient liquid chromatography–
tandem mass spectrometry (LC–MS/MS) via electrospray ionization were obtained using …