Conditional gene expression has greatly facilitated the examination of the functions of
particular gene products. Using the Cre/lox P switching expression system, we plan to …

With the recent developments of adoptive T cell therapies and the use of new monoclonal
antibodies against the immune checkpoints, immunotherapy is at a turning point. Key …

Mouse studies have shown that the immune system can reject tumours, and the
identification of tumour antigens that can be recognized by human T cells has facilitated the …

Shigella spp. are gram-negative pathogenic bacteria that evolved from harmless
enterobacterial relatives and may cause devastating diarrhea upon ingestion. Research …

MHC class I molecules bind short peptides and present them to CD8+ T cells. Contrary to
textbook descriptions, the generation of MHC class-I-associated peptides from endogenous …

Epitopes presented by major histocompatibility complex (MHC) class I molecules are
selected by a multi-step process. Here we present the first computational prediction of this …

MHC-class-I-presented peptides are predominantly generated by the proteasome system.
IFN-γ strongly influences the processing efficiency by inducing immunoproteasome …

Peptides presented by major histocompatibility complex class I molecules are derived
mainly from cytosolic oligopeptides generated by proteasomes during the degradation of …

Crosspresentation is a specialized function of myeloid dendritic cells (mDCs), allowing them
to induce CD8+ T cell responses against exogenous antigens that are not directly produced …

Mutations within cytotoxic T lymphocyte (CTL) epitopes impair T cell recognition, but escape
mutations arising in flanking regions that alter antigen processing have not been defined in …