Rapid advances in nanopore technologies for sequencing single long DNA and RNA
molecules have led to substantial improvements in accuracy, read length and throughput …

Long-read DNA sequencing technologies have been rapidly evolving in recent years, and
their ability to assess large and complex regions of the genome makes them ideal for clinical …

Extensive investigation of gene fusions in cancer has led to the discovery of novel
biomarkers and therapeutic targets. To date, most studies have neglected chromosomal …

Long-read single-cell RNA sequencing (scRNA-seq) enables the quantification of RNA
isoforms in individual cells. However, long-read scRNA-seq using the Oxford Nanopore …

Abstract Single-molecule Real-time Isoform Sequencing (Iso-seq) of transcriptomes by
PacBio can generate very long and accurate reads, thus providing an ideal platform for full …

Genes generate transcripts of various functions by alternative splicing. However, in most
transcriptome studies, short-reads sequencing technologies (next-generation sequencers) …

Transcriptome profiling is a mainstay of translational cancer research and is increasingly
finding its way into precision oncology. While bulk RNA sequencing (RNA-seq) is widely …

Long-read RNA sequencing (RNA-seq) is emerging as a powerful and versatile technology
for studying human transcriptomes. By enabling the end-to-end sequencing of full-length …

Gene fusions are prevalent in a wide array of cancer types with different frequencies. Long-
read transcriptome sequencing technologies, such as PacBio, Iso-Seq, and Nanopore direct …

Single-cell sequencing technologies have revolutionised the life sciences and biomedical
research. Single-cell sequencing provides high-resolution data on cell heterogeneity …