As the main biomarkers of most diseases, enzymes play fundamental but extremely critical
roles in biosystems. High-resolution studies of enzymes using activatable in situ …

Fluorescence-guided surgery using tumour-targeted imaging agents has emerged over the
past decade as a promising and effective method of intraoperative cancer detection. An …

Near‐infrared (NIR) activatable fluorescent probes have been considered to be the effective
edge tools for the investigation of cell biology and disease diagnosis because of their …

Abnormal enzymatic activities are directly related to the development of cancers. Identifying
the location and expression levels of these enzymes in live cancer cells have considerable …

Surgical resection of cancer remains an important treatment modality. Despite advances in
preoperative imaging, surgery itself is primarily guided by the surgeon's ability to locate …

Fluorophores and probes are invaluable for the visualization of the location and dynamics of
gene expression, protein expression, and molecular interactions in complex living systems …

Activity-based protein profiling (ABPP) is a technique that uses highly selective active-site
targeted chemical probes to label and monitor the state of proteins. ABPP integrates the …

The long wavelength (far-red to NIR) analyte-responsive fluorescent probes are
advantageous for in vivo bioimaging because of minimum photo-damage to biological …

It is more than 50years since the lysosome was discovered. Since then its hydrolytic
machinery, including proteases and other hydrolases, has been fairly well identified and …

Fluorescent probes have long been valuable tools in the study of biological systems. With
the ever-expanding range of known enzymatic biomarkers for disease, it has never been …