Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

The complement system plays a key role in pathogen immunosurveillance and tissue
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …

Complement is an important component of the innate immune system that is crucial for
defense from microbial infections and for clearance of immune complexes and injured cells …

Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Ischemia/reperfusion injury is an unavoidable relevant consequence after kidney
transplantation and influences short term as well as long-term graft outcome. Clinically …

The crosstalk among the complement system, immune cells, and mediators of inflammation
provides an efficient mechanism to protect the organism against infections and support the …

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of
potentially life-threatening autoimmune diseases. The main histological feature in the …

Organ transplantation appears today to be the best alternative to replace the loss of vital
organs induced by various diseases. Transplants can, however, also be rejected by the …

Ex vivo normothermic machine perfusion (NMP) is a new clinical strategy to assess and
resuscitate organs likely to be declined for transplantation, thereby increasing the number of …

The immune response after brain injury is highly complex and involves both local and
systemic events at the cellular and molecular level. It is associated to a dramatic over …