Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

Recent studies applying advanced imaging techniques are changing the way we
understand bacterial cell surfaces, bringing new knowledge on everything from single-cell …

INTRODUCTION Despite their key biological roles, only a few proteins that fold into lipid
membranes have been designed de novo. A class of membrane proteins—transmembrane …

Gram-negative bacteria are surrounded by a protective outer membrane (OM) with
phospholipids in its inner leaflet and lipopolysaccharides (LPS) in its outer leaflet. The OM is …

Biological membranes consist of two leaflets of phospholipid molecules that form a bilayer,
each leaflet comprising a distinct lipid composition. This asymmetry is created and …

Transmembrane β barrel proteins are folded into the outer membrane (OM) of Gram-
negative bacteria by the β barrel assembly machinery (BAM) via a poorly understood …

The Omp85 protein superfamily is found in the outer membrane (OM) of all gram-negative
bacteria and eukaryotic organelles of bacterial origin. Members of the family catalyze both …

The outer membrane is a formidable barrier that protects Gram-negative bacteria against
environmental threats. Its integrity requires the correct folding and insertion of outer …

Sepsis is a life-threatening condition characterized by an uncontrolled inflammatory
response to an infectious agent and its antigens. Immune cell activation against the antigens …

The outer lipopolysaccharide (LPS) membrane of Gram-negative bacteria forms the main
barrier for transport of antimicrobial molecules into the bacterial cell. In this study we develop …