The visual/β-arrestins, a small family of proteins originally described for their role in the
desensitization and intracellular trafficking of G protein–coupled receptors (GPCRs), have …

When ubiquitin (Ub) is attached to membrane proteins on the plasma membrane, it directs
them through a series of sorting steps that culminate in their delivery to the lumen of the …

Thioredoxin-interacting protein (TXNIP) is an α-arrestin family protein that is induced in
response to glucose elevation. It has been shown to provide a negative feedback loop to …

The nuclear envelope is a double membrane that separates the nucleus from the cytoplasm.
The inner nuclear membrane (INM) functions in essential nuclear processes including …

Potassium (K+) homeostasis is tightly regulated for optimal cell and organismal health.
Failure to control potassium balance results in disease, including cardiac arrythmias and …

Most malignant cells display increased glucose absorption and metabolism compared to
surrounding tissues. This well-described phenomenon results from a metabolic …

Protein quality control (PQC) machineries play a critical role in selective identification and
removal of mistargeted, misfolded, and aberrant proteins. This task is extremely complicated …

One of the major bottlenecks in lactic acid production using microbial fermentation is the
detrimental influence lactic acid accumulation poses on the lactic acid producing cells. The …

Plasma membrane lipid composition must be maintained during growth and under
environmental insult. In yeast, signaling mediated by TOR Complex 2 (TORC2)-dependent …

Alpha-synuclein (aSyn) is the main component of proteinaceous inclusions known as Lewy
bodies (LBs), the typical pathological hallmark of Parkinson's disease (PD) and other …