Immunoglobulins or antibodies are the main effector molecules of the B-cell lineage and are
encoded by hundreds of variable (V), diversity (D), and joining (J) germline genes, which …

Definition of the specific germline immunoglobulin (Ig) alleles present in an individual is a
critical first step to delineate the ontogeny and evolution of antigen-specific antibody …

The human immunoglobulin repertoire is a hugely diverse set of sequences that are formed
by processes of gene rearrangement, heavy and light chain gene assortment, class …

Abstract Analysis of antibody repertoires by high-throughput sequencing is of major
importance in understanding adaptive immune responses. Our knowledge of variations in …

Immunoglobulin heavy chain (IGH) germline gene variations influence the B cell receptor
repertoire, with resulting biological consequences such as shaping our response to …

Abstract Analysis of antibody repertoire development and specific antibody responses
important for eg autoimmune conditions, allergy, and protection against disease is …

The V (D) J recombination forms the immunoglobulin genes by joining the variable (V),
diversity (D), and joining (J) germline genes. Since variations in germline genes have been …

Extensive diversity has been identified in the human heavy chain immunoglobulin locus,
including allelic variation, gene duplication, and insertion/deletion events. Several genes …

B cells produce antibodies, key effector molecules in health and disease. They mature their
properties, including their affinity for antigen, through hypermutation events; processes that …

The antibody response to SARS-CoV-2 shows biased immunoglobulin heavy chain variable
(IGHV) gene usage, allowing definition of genetic signatures for some classes of neutralizing …