Molecular layer interneurons (MLIs) play an important role in cerebellar information
processing by controlling Purkinje cell (PC) activity via inhibitory synaptic transmission. A …

Fragile X syndrome (FXS), the most common form of inherited intellectual disability, is due to
the functional deficiency of the fragile X mental retardation protein (FMRP), an RNA-binding …

The prevailing belief has been that the fundamental structures of cerebellar neuronal
circuits, consisting of a few major neuron types, are simple and well understood. Given that …

Purkinje cells receive synaptic input from several classes of interneurons. Here, we address
the roles of inhibitory molecular layer interneurons in establishing Purkinje cell function in …

Thyroid hormones (THs) regulate gene expression by binding to nuclear TH receptors (TRs)
in the cell. THs are indispensable for brain development. However, we have little knowledge …

Inhibitory interneurons integrate into developing circuits in specific ratios and distributions. In
the neocortex, inhibitory network formation occurs concurrently with the apoptotic elimination …

Premature infants are more likely to develop locomotor disorders than term infants. In a
chronic sub-lethal hypoxia (Hx) mouse model of neonatal brain injury, we recently …

Ramón y Cajal proclaimed the neuron doctrine based on circuit features he exemplified
using cerebellar basket cell projections. Basket cells form dense inhibitory plexuses that …

Cerebellar granule neurons (CGNs) undergo programmed cell death during the first
postnatal week of mouse development, coincident with sustained expression of the death …

Neuronal activity is believed to be important for brain development; however, it remains
unclear as to how spatiotemporal distributions of synaptic excitation contribute to neural …