P2X receptors are membrane ion channels that open in response to the binding of
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

The charge of this invited review is to present a convincing case for the fact that cells release
their ATP for physiological reasons. Many of our “purinergic” colleagues as well as …

Extracellular ATP is a signaling molecule exploited by the immune cells for both autocrine
regulation and paracrine communication. By performing live calcium imaging experiments …

This review is a historical account about purinergic signalling in the heart, for readers to see
how ideas and understanding have changed as new experimental results were published …

The P2X4 receptor has a widespread distribution in the central nervous system and the
periphery, and plays an important role in the function of immune cells and the vascular …

Neurons of the central nervous system (CNS) are endowed with ATP-sensitive receptors
belonging to the P2X (ligand-gated cationic channels) and P2Y (G protein-coupled …

The adenosine 5′-triphosphate-gated P2X4 receptor channel is a promising target in
neuroinflammatory disorders, but the ability to effectively target these receptors in models of …

P2X receptors are ligand‐gated ion channels activated by extracellular ATP. In expression
systems, P2X subunits form homo‐and heterotrimeric receptors. Heteromerization is also …

Investigation of rat recombinant P2X6 receptors has been limited because of the difficulty in
obtaining functional expression in heterologous systems. In this study, we demonstrate …